Molecular Localization of Human Papillomaviru_18 (HPV_18) in Tissues from Thyroid Carcinoma in Mid-Euphrates

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Shakir H. Mohammed
Ausama Abed-Alkadum Alajeely
A.A Amber H Abdul Ameer
Saad Hasan Mohammed Ali
Ahmed Abbas Abed_ Azuwaid

Abstract

Background: THilnahyroid cancer is a cancer that starts in the thyroid gland and thought to be related to a number of environmental and genetic predisposing factors .Human Papil- loma Virus (HPV) the virus that causes cervical cancer ,is also linked to throat cancer and is one among their associated infective agents.


Objective: This study aimed at detecting DNA of HPV genotype-18 using in situ hybridization technique in thyroid tissues from benign thyroid hyperplasia and thyroid car- cinoma, and elucidate the association between this HPV-18 and thyroid carcinogenesis.


Patients and Methods: Sixty (60) formalin-fixed, paraffin embedded thyroid tissue blocks were obtained ,among them (30) tissue biopsies from thyroid carcinoma with grade I and (20) benign thyroid neoplasm tissue blocks as well as (10) autopsies from apparently normal thyroid tissues were collected from the archives of Forensic Medicine Institute / Babil and used as thyroid healthy control group. Detection of HPV-18 was done by using highly sensitive version of in situ hybridization technique.


Results: Among malignant thyroid tumors 56.7% patients had HPV-18 while 35% HPV- 18 positivity was detected in benign thyroid tumor group. None of healthy thyroid tissues revealed ISH reactions. There was 32.7% female had HPV-18, and 24% male had HPV-18. No significant statistical associations were noticed between the presence of HPV-18 and the age of those patients.


Conclusion: Human Papilloma virus genotype-18 could share a role in pathogenesis of this group of patients with thyroid cancers.

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How to Cite
[1]
“Molecular Localization of Human Papillomaviru_18 (HPV_18) in Tissues from Thyroid Carcinoma in Mid-Euphrates”, JUBPAS, vol. 26, no. 6, pp. 84–94, May 2018, Accessed: Mar. 28, 2024. [Online]. Available: https://journalofbabylon.com/index.php/JUBPAS/article/view/1406
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How to Cite

[1]
“Molecular Localization of Human Papillomaviru_18 (HPV_18) in Tissues from Thyroid Carcinoma in Mid-Euphrates”, JUBPAS, vol. 26, no. 6, pp. 84–94, May 2018, Accessed: Mar. 28, 2024. [Online]. Available: https://journalofbabylon.com/index.php/JUBPAS/article/view/1406

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