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The present study was conducted to confirm the effects and correlations of estradiol hormone on some major clotting factors (fibrinogen FI , prothrombin FII, stable factor F VII, antihemophilic factor FVIII, and chrismas factor IX) during pregnancy phases. Seventy five (75) pregnant women at different stages of pregnancy and were sub- divided into third groups according to period of gestational phases , included twenty five (25) pregnant women in each group (first, second, third trimesters). Twenty (20) volunteer non-pregnant non-lactating women were involved in this study and used as a control group. All ages of tested women ( pregnant and non- pregnant) were between 25 year to 35 year old . Regarding levels of estradiol hormone , they were showed insignificant elevation (p>0.05) during first trimester and remarkable increase (p< 0.05) during second and third trimesters when matched with their counterparts of non- pregnant group. About concentrations of fibrinogen factor (FI) , they were indicated a significant heightening (p< 0.05) during all phases of pregnancy in matching with control group, and these concentrations have a positive correlation (r =0.714) with levels of estradiol. Activities of prothrombin factor ( F II) were significantly elevated (p<0.05) throughout pregnancy phases than of non- pregnant women , and have a significant positive correlation ( r =0. 532) with estradiol hormone . Levels of stable factor (F VII ) activity indicated insignificant increase (p> 0.05 ) in first and second trimesters and its activities become increased (p< 0.05) at third trimester in a comparison with those of control group, and pointed out a significant positive correlation ( r = 0.412 ) with estradiol level . Estimation of intrinsic pathway activities (antihemophlic factor FVIII and Chrismas factor FIX ) were showed a progressive elevation (p< 0.05) during first, second, and third trimesters in a comparison with control group, and these activities confirmed a significant positive correlation (r =0.260 , r =0.632, respectively) with estradiol.