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Psoriasis is one of most common autoimmune cutaneous diseases of the human communities, current study was aimed to determine the role of T-reg in patients with Psoriasis .Obtained data explained that psorasis is widely distributed disease at Al-Diwanyia city withen different age groups, the most affected group was the group (1-20) years old followed by the group (21-40) years old with tendency to males than females. ). The relative gene expression in FoxP3 gene showed increment in patients group (7.89±5.82) compared with control group which was (1.91±1.25), NFAT gene showed increment in patients group (7.66±3.27) compared with control group which was (3.002±0.86). AP1gene showed an increment in patients group (5.34±1.08) compared with control group which was (1.88±1.25). Serum profile of TNF-α in patients appeared to be elevated (194±32.9) pg/ml than control group (112±18.6) pg/ml. Obtained data also indicated a remarkable increase in serum concentrations of IL-36 (149.6±31.3)pg/ml, in comparison to control group (37.4±9.9) pg/ml. Over all findings reflect the abnormal increased activity of both T-reg and the effector cells which result in the progression of psoriasis.