Correlation between Anti cyclic-citrullinated-‎eptide and rheumatoid Factor Antibodies ‎‎“levels in” Patients with from Rheumatoid ‎Arthritis

Abstract

To  identify  diagnostic   utilities  of   Anti   citrullinated   protein   (ACCP)   and Rheumatoid   factor  (RF)   are  autoantibodies (Abs  directly  against an self-individual antigens),  Analytical  study.  The  questioner  reported  for  50  patients  with  RA were collected  from  Department  of  Rheumatology¸  AL˗Sader  Teaching  Hospital.  Serum levels  of  RF & (ACCP)  Abs  were  determinated  by enzyme ˗ linked immunosorbent assay”, while  the  level  of  erythrocyte  sedimentation  rate  (ESR)  was determined by westergreen  method.   Distribution  of  RA occur  in  females  more  than  males which  reached  (80%)  &  (20%)  respectively  according  to  the  patients group. The patients divided  according  to the  age  into  three  groups (<30)¸ (30˗50) &  (>50). The  percent for  these  groups  were  (16%)¸ (52%) & (32%). Among the 50 patients with RA¸ CCP and  ESR  49  patients  (98%)  tested  positive  for  (ACCP)  antibodies¸ and 22 patients (44%)  tested  positive for RF. and 37  patients(74% ) tested increasing levels of ESR in RA  patients. The  mean  value of (ACCP) & ESR shows highly significance  (P<0∙05), while the  RF serum  levels increase significantly. Demonstrate  the (ACCP) antibodies assay is a useful test for diagnosing RA. However, the use of RF and (ACCP)auto- antibodies  in  combination  further  elevated   the diagnostic  value  for  RA